
Indinavir sulfate
CAS No. 157810-81-6
Indinavir sulfate( MK-639 sulfate | L735524 sulfate )
Catalog No. M20547 CAS No. 157810-81-6
Indinavir is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.
Purity : >98% (HPLC)






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50MG | 43 | In Stock |
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100MG | 71 | In Stock |
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200MG | Get Quote | In Stock |
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Biological Information
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Product NameIndinavir sulfate
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NoteResearch use only, not for human use.
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Brief DescriptionIndinavir is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.
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DescriptionIndinavir is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.
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In VitroCell Viability Assay Cell Line:PBMCs (from healthy and HIV-infected volunteers)Concentration:0-50 μMIncubation Time:18 h (pretreatment; stimulation with anti-CD3 for an additional 48 hours)Result:Blocked anti-CD3-induced cell-cycle progression in a dose-dependent manner.Resulted in dose-dependent reduction of lymphoproliferative responses.Cell Invasion Assay Cell Line:Huh7 and SK-HEP-1 cells Concentration:40 μM-40 nM Incubation Time:5 days Result:Reduced ability to invade an in vitro constituted extracellular matrix for both cell lines treated compared with the untreated cells.Western Blot Analysis Cell Line:Huh7 and SK-HEP-1 cells Concentration:40 μM-40 nM Incubation Time:48 h Result:Blocked the conversion of latent MMP-2 to its 62/64-kDa active form.
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In VivoAnimal Model:Nude mice(s.c. into Huh7 and SK-HEP-1 cells).Dosage:70 mg/kg Administration:Oral gavage; once a day for 3 weeks. Result:Delaied the growth of s.c. implanted hepatocarcinoma xenografts in nude mice compared with placebo.
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SynonymsMK-639 sulfate | L735524 sulfate
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV Protease
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Research AreaInflammation/Immunology
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IndicationHIV infection.
Chemical Information
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CAS Number157810-81-6
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Formula Weight711.87
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Molecular FormulaC36H49N5O8S
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (140.48 mM)
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SMILESOS(O)(=O)=O.CC(C)(C)NC(=O)C1CN(Cc2cccnc2)CCN1CC(O)CC(Cc1ccccc1)C(=O)NC1C(O)Cc2ccccc12
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Chemical Name(S)-1-((2S4R)-4-benzyl-2-hydroxy-5-(((1S2R)-2-hydroxy-23-dihydro-1H-inden-1-yl)amino)-5-oxopentyl)-N-(tert-butyl)-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide sulfate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ekins S Mathews P Saito E K et al. α7-Nicotinic acetylcholine receptor inhibition by indinavir: implications for cognitive dysfunction in treated HIV disease[J]. AIDS (London England) 2017 31(8).
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